Copovidone

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Copovidone is a vinylpyrrolidone-vinyl acetate copolymer that is soluble both in water and in alcohols.

It is used in the pharmaceutical industry as binders, granulating agents, retarding agents and film, Forming agents in drugs.

Copovidone meets the requirements of the latest USP/NF, Ph.Eur. and JPE

Characteristics

Appearance

White or slightly yellowish, free-flowing powder.

Odour

Odor and practically no taste.

Solubility

Copovidone readily dissolves in all hydrophilic solvents. Solutions of more than 10 % concentration can be pre-pared in: water; ethanol; isopropanol; methylene chloride; glycerol; propylene glycol; it is less soluble in: ether; cyclic, aliphatic and alicyclic hydrocarbons.

Applications

Binder for tablets and granules

Is an excellent binder for tablets and granules.

Dry binder for direct compression Wet granulation

Between 2 % and 5 %, as a proportion of the final weight of the preparation, is usually used.

Film-coating

Forms films that are soluble at all Ph values.

Subcoating Sugar-coating Sprays Controlled-release preparations

Is used in sugar-coating to improve the adhesion of the coating to the surface of the tablet core and to increase the capacity of the coating solution for pigments and improve their dispersibility.